Robert A Brodsky Selected Research

GPI-Linked Proteins

1/2017	A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model.
10/2014	Paroxysmal nocturnal hemoglobinuria.
11/2013	Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition.
4/2009	Silencing of genes required for glycosylphosphatidylinositol anchor biosynthesis in Burkitt lymphoma.
3/2008	Advances in the diagnosis and therapy of paroxysmal nocturnal hemoglobinuria.
4/2004	Enhanced cytotoxicity of rituximab following genetic and biochemical disruption of glycosylphosphatidylinositol anchored proteins.

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Robert A Brodsky Research Topics

Disease

43	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 04/2022 - 04/2004
35	Hemolysis 04/2022 - 01/2006
19	Graft vs Host Disease (Graft-Versus-Host Disease) 11/2020 - 04/2006
17	Thrombosis (Thrombus) 01/2022 - 07/2004
17	Aplastic Anemia (Anemia, Hypoplastic) 01/2020 - 03/2002
13	Atypical Hemolytic Uremic Syndrome 04/2022 - 01/2015
10	Fatigue 11/2021 - 01/2006
10	Thrombotic Microangiopathies 01/2021 - 01/2015
8	Anemia 01/2022 - 02/2008
7	Hemolytic Anemia 11/2021 - 04/2008
7	Hematologic Neoplasms (Hematological Malignancy) 01/2018 - 06/2008
6	Infections 04/2022 - 12/2015
6	Autoimmune Diseases (Autoimmune Disease) 12/2021 - 04/2004
6	Bone Marrow Failure Disorders 11/2021 - 06/2009
6	Sickle Cell Anemia (Hemoglobin S Disease) 01/2021 - 03/2009
5	Autoimmune Hemolytic Anemia (Cold Agglutinin Disease) 01/2022 - 07/2002
5	Thrombotic Thrombocytopenic Purpura 12/2021 - 01/2015
5	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 01/2021 - 01/2019
4	HELLP Syndrome 04/2022 - 05/2016
4	Stroke (Strokes) 01/2022 - 01/2019
4	Thrombocytopenia (Thrombopenia) 01/2022 - 02/2008
4	Chronic Disease (Chronic Diseases) 11/2021 - 09/2006
4	Muscle Hypotonia (Hypotonia) 11/2017 - 03/2014
4	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 12/2014 - 05/2004
4	Neoplasms (Cancer) 08/2014 - 09/2006
4	Diffuse Esophageal Spasm (Esophageal Spasm) 06/2011 - 01/2006
3	Myasthenia Gravis 01/2020 - 03/2005
3	Protein Deficiency 10/2014 - 01/2009
3	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 08/2014 - 04/2004
3	Multiple Sclerosis 02/2012 - 03/2005
3	Erectile Dysfunction 03/2008 - 01/2006
2	Myocardial Infarction 01/2022 - 12/2021
2	COVID-19 01/2022 - 10/2020
2	Thromboembolism 01/2022 - 12/2007
2	Chronic Renal Insufficiency 12/2021 - 07/2013
2	Hypertension (High Blood Pressure) 12/2021 - 01/2019
2	Pain (Aches) 01/2021 - 01/2006
2	Leukemia 01/2021 - 03/2013
2	Hemoglobinuria 12/2020 - 05/2009
2	Multiple Myeloma 11/2017 - 05/2003
2	Disease Progression 01/2016 - 05/2005
2	Seizures (Absence Seizure) 10/2014 - 03/2014
2	Burkitt Lymphoma (Burkitt's Lymphoma) 03/2013 - 04/2009
2	Relapsing-Remitting Multiple Sclerosis 02/2012 - 08/2008
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 05/2010 - 01/2003
2	Budd-Chiari Syndrome (Budd Chiari Syndrome) 05/2009 - 02/2006
2	Pancytopenia 08/2008 - 05/2005
1	Severe Acute Respiratory Syndrome 01/2022
1	Renal Insufficiency (Renal Failure) 01/2022
1	Diabetes Mellitus 12/2021
1	Hyperlipidemias (Hyperlipidemia) 12/2021
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2021
1	Obesity 12/2021
1	Atrial Fibrillation 12/2021

Drug/Important Bio-Agent (IBA)

43	Cyclophosphamide (Cytoxan)FDA LinkGeneric 11/2020 - 03/2002
40	Complement System Proteins (Complement)IBA 04/2022 - 04/2004
26	eculizumab FDA Link 11/2021 - 09/2006
13	Complement Inactivating AgentsIBA 11/2021 - 09/2006
13	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 01/2021 - 05/2005
11	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2007
6	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 12/2020 - 09/2006
6	Monoclonal AntibodiesIBA 01/2017 - 04/2004
6	GPI-Linked ProteinsIBA 01/2017 - 04/2004
5	Hemoglobins (Hemoglobin)IBA 01/2013 - 01/2006
4	Antilymphocyte Serum (Anti-Thymocyte Globulin)IBA 11/2016 - 05/2005
3	EnzymesIBA 04/2022 - 05/2016
3	AutoantibodiesIBA 01/2022 - 01/2015
3	ravulizumabIBA 03/2021 - 12/2020
3	Antiphospholipid AntibodiesIBA 01/2021 - 01/2019
3	Mycophenolic Acid (Cellcept)FDA LinkGeneric 01/2019 - 11/2012
3	Tacrolimus (Prograf)FDA LinkGeneric 01/2018 - 11/2012
3	Rituximab (Mabthera)FDA Link 12/2015 - 04/2004
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 06/2011 - 10/2007
2	Complement Factor D (Factor D)IBA 01/2022 - 01/2017
2	AntigensIBA 01/2022 - 10/2019
2	pegcetacoplanIBA 01/2022 - 11/2020
2	TESIBA 01/2022 - 07/2013
2	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 01/2022 - 11/2021
2	danicopanIBA 11/2021 - 01/2017
2	AntibodiesIBA 01/2020 - 01/2008
2	Sirolimus (Rapamycin)FDA Link 01/2019 - 11/2012
2	thiamine triphosphorate (TTP)IBA 01/2019 - 06/2015
2	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2018 - 11/2005
2	Pharmaceutical PreparationsIBA 01/2017 - 11/2013
2	Cyclosporine (Ciclosporin)FDA LinkGeneric 11/2016 - 05/2005
2	Immunoglobulin M (IgM)IBA 11/2015 - 01/2015
2	proaerolysinIBA 08/2012 - 04/2009
2	DNA (Deoxyribonucleic Acid)IBA 01/2011 - 04/2009
1	Oxygen (Dioxygen)IBA 01/2022

Therapy/Procedure

28	Therapeutics 11/2021 - 03/2005
21	Transplantation 11/2020 - 05/2003
18	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2020 - 03/2002
4	Hematopoietic Stem Cell Transplantation 01/2021 - 01/2003
3	Stem Cell Transplantation 08/2014 - 01/2003
2	Drug Therapy (Chemotherapy) 02/2015 - 01/2003
2	Homologous Transplantation 12/2014 - 04/2006
2	Salvage Therapy 11/2011 - 05/2004
2	Erythrocyte Transfusion 03/2008 - 10/2007
2	Immunotherapy 01/2008 - 03/2005
1	Artificial Respiration (Mechanical Ventilation) 01/2022